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[Pandemic influenza A in the ICU: experience in Spain and Latin America. GETGAG/SEMICYUC/(Spanish Working Group on Severe Pandemic Influenza A/SEMICYUC)].

Identifieur interne : 000448 ( Main/Exploration ); précédent : 000447; suivant : 000449

[Pandemic influenza A in the ICU: experience in Spain and Latin America. GETGAG/SEMICYUC/(Spanish Working Group on Severe Pandemic Influenza A/SEMICYUC)].

Auteurs : A. Rodríguez [Espagne] ; L. Socías ; J E Guerrero ; J C Figueira ; N. González ; E. Maraví-Poma ; L. Lorente ; M. Martín ; A. Albaya-Moreno ; A. Algora-Weber ; J. Vallés ; C. Le N-Gil ; T. Lisboa ; C. Balasini ; M. Villab N ; R. Pérez-Padilla ; D. Barahona ; J. Rello

Source :

RBID : pubmed:20061066

Descripteurs français

English descriptors

Abstract

INTRODUCTION

Pandemic Influenza A (H1N1)v infection is the first pandemic in which intensive care units (ICU) play a fundamental role. It has spread very rapidly since the first cases were diagnosed in Mexico with the subsequent spread of the virus throughout the Southern Cone and Europe during the summer season.

OBJECTIVE

This study has aimed to compare the clinical presentation and outcome among the critical patients admitted to the ICU until July 31, 2009 in Spain with some series from Latin America.

MATERIAL AND METHOD

Six series of critically ill patients admitted to the ICU were considered. Clinical characteristics, complications and outcome were compared between series.

RESULTS

Young patients (35-45 years) with viral pneumonia as a predominant ICU admission cause with severe respiratory failure and a high need of mechanical ventilation (60-100%) were affected. Obesity, pregnancy and chronic lung disease were risk factors associated with a worse outcome, however there was a high number of patients without comorbidities (40-50%). Mortality rate was between 25-50% and higher in the Latin America series, demonstrating the specific potential pathogenesis of the new virus. The use of antiviral treatment was delayed (between 3 and 6 days) and not generalized, with greater delay in Latin America in regards to Spain.

CONCLUSIONS

These data suggest that a more aggressive treatment strategy, with earlier and easier access to the antiviral treatment might reduce the number of ICU admissions and mortality.


DOI: 10.1016/j.medin.2009.12.005
PubMed: 20061066


Affiliations:


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Le document en format XML

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<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Comorbidity (MeSH)</term>
<term>Disease Outbreaks (MeSH)</term>
<term>Female (MeSH)</term>
<term>Hospital Mortality (MeSH)</term>
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<term>Influenza, Human (drug therapy)</term>
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<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Oseltamivir (therapeutic use)</term>
<term>Pregnancy (MeSH)</term>
<term>Pregnancy Complications, Infectious (epidemiology)</term>
<term>Pregnancy Complications, Infectious (virology)</term>
<term>Registries (MeSH)</term>
<term>Respiration, Artificial (statistics & numerical data)</term>
<term>Respiratory Insufficiency (etiology)</term>
<term>Respiratory Insufficiency (therapy)</term>
<term>Severity of Illness Index (MeSH)</term>
<term>Shock (etiology)</term>
<term>Spain (epidemiology)</term>
<term>Young Adult (MeSH)</term>
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<term>Adulte d'âge moyen (MeSH)</term>
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<term>Antiviraux (usage thérapeutique)</term>
<term>Choc (étiologie)</term>
<term>Comorbidité (MeSH)</term>
<term>Complications infectieuses de la grossesse (virologie)</term>
<term>Complications infectieuses de la grossesse (épidémiologie)</term>
<term>Enregistrements (MeSH)</term>
<term>Espagne (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>Grippe humaine (complications)</term>
<term>Grippe humaine (traitement médicamenteux)</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Grossesse (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Insuffisance respiratoire (thérapie)</term>
<term>Insuffisance respiratoire (étiologie)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mortalité hospitalière (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Oséltamivir (usage thérapeutique)</term>
<term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Unités de soins intensifs (statistiques et données numériques)</term>
<term>Ventilation artificielle (statistiques et données numériques)</term>
<term>Épidémies de maladies (MeSH)</term>
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<term>Antiviral Agents</term>
<term>Oseltamivir</term>
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<term>Influenza, Human</term>
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<term>Influenza, Human</term>
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<term>Influenza, Human</term>
<term>Latin America</term>
<term>Pregnancy Complications, Infectious</term>
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<term>Shock</term>
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<term>Sous-type H1N1 du virus de la grippe A</term>
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<term>Respiration, Artificial</term>
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<term>Unités de soins intensifs</term>
<term>Ventilation artificielle</term>
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<term>Respiratory Insufficiency</term>
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<term>Insuffisance respiratoire</term>
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<term>Grippe humaine</term>
<term>Oséltamivir</term>
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<term>Complications infectieuses de la grossesse</term>
<term>Grippe humaine</term>
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<term>Influenza, Human</term>
<term>Pregnancy Complications, Infectious</term>
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<term>Amérique latine</term>
<term>Complications infectieuses de la grossesse</term>
<term>Espagne</term>
<term>Grippe humaine</term>
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<term>Choc</term>
<term>Insuffisance respiratoire</term>
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<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Comorbidity</term>
<term>Disease Outbreaks</term>
<term>Female</term>
<term>Hospital Mortality</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pregnancy</term>
<term>Registries</term>
<term>Severity of Illness Index</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Comorbidité</term>
<term>Enregistrements</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Indice de gravité de la maladie</term>
<term>Jeune adulte</term>
<term>Mortalité hospitalière</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
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<front>
<div type="abstract" xml:lang="en">
<p>
<b>INTRODUCTION</b>
</p>
<p>Pandemic Influenza A (H1N1)v infection is the first pandemic in which intensive care units (ICU) play a fundamental role. It has spread very rapidly since the first cases were diagnosed in Mexico with the subsequent spread of the virus throughout the Southern Cone and Europe during the summer season.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>OBJECTIVE</b>
</p>
<p>This study has aimed to compare the clinical presentation and outcome among the critical patients admitted to the ICU until July 31, 2009 in Spain with some series from Latin America.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>MATERIAL AND METHOD</b>
</p>
<p>Six series of critically ill patients admitted to the ICU were considered. Clinical characteristics, complications and outcome were compared between series.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>Young patients (35-45 years) with viral pneumonia as a predominant ICU admission cause with severe respiratory failure and a high need of mechanical ventilation (60-100%) were affected. Obesity, pregnancy and chronic lung disease were risk factors associated with a worse outcome, however there was a high number of patients without comorbidities (40-50%). Mortality rate was between 25-50% and higher in the Latin America series, demonstrating the specific potential pathogenesis of the new virus. The use of antiviral treatment was delayed (between 3 and 6 days) and not generalized, with greater delay in Latin America in regards to Spain.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSIONS</b>
</p>
<p>These data suggest that a more aggressive treatment strategy, with earlier and easier access to the antiviral treatment might reduce the number of ICU admissions and mortality.</p>
</div>
</front>
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<Title>Medicina intensiva</Title>
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<ArticleTitle>[Pandemic influenza A in the ICU: experience in Spain and Latin America. GETGAG/SEMICYUC/(Spanish Working Group on Severe Pandemic Influenza A/SEMICYUC)].</ArticleTitle>
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<AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Pandemic Influenza A (H1N1)v infection is the first pandemic in which intensive care units (ICU) play a fundamental role. It has spread very rapidly since the first cases were diagnosed in Mexico with the subsequent spread of the virus throughout the Southern Cone and Europe during the summer season.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">This study has aimed to compare the clinical presentation and outcome among the critical patients admitted to the ICU until July 31, 2009 in Spain with some series from Latin America.</AbstractText>
<AbstractText Label="MATERIAL AND METHOD" NlmCategory="METHODS">Six series of critically ill patients admitted to the ICU were considered. Clinical characteristics, complications and outcome were compared between series.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Young patients (35-45 years) with viral pneumonia as a predominant ICU admission cause with severe respiratory failure and a high need of mechanical ventilation (60-100%) were affected. Obesity, pregnancy and chronic lung disease were risk factors associated with a worse outcome, however there was a high number of patients without comorbidities (40-50%). Mortality rate was between 25-50% and higher in the Latin America series, demonstrating the specific potential pathogenesis of the new virus. The use of antiviral treatment was delayed (between 3 and 6 days) and not generalized, with greater delay in Latin America in regards to Spain.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These data suggest that a more aggressive treatment strategy, with earlier and easier access to the antiviral treatment might reduce the number of ICU admissions and mortality.</AbstractText>
<CopyrightInformation>Copyright 2009 Elsevier España, S.L. y SEMICYUC. All rights reserved.</CopyrightInformation>
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<LastName>Villabón</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Pérez-Padilla</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Barahona</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y">
<LastName>Rello</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y">
<CollectiveName>Grupo Español de Trabajo de Gripe A Grave/Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias</CollectiveName>
</Author>
</AuthorList>
<Language>spa</Language>
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<PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<VernacularTitle>Gripe A pandémica en una unidad de cuidados intensivos: experiencia en España y Latinoamérica (Grupo Español de Trabajo de Gripe A Grave/Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias).</VernacularTitle>
<ArticleDate DateType="Electronic">
<Year>2010</Year>
<Month>01</Month>
<Day>12</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>Spain</Country>
<MedlineTA>Med Intensiva</MedlineTA>
<NlmUniqueID>9207689</NlmUniqueID>
<ISSNLinking>0210-5691</ISSNLinking>
</MedlineJournalInfo>
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<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>20O93L6F9H</RegistryNumber>
<NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList>
<CommentsCorrections RefType="CommentIn">
<RefSource>Med Intensiva. 2010 Aug-Sep;34(6):431</RefSource>
<PMID Version="1">20537427</PMID>
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<MeshHeading>
<DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
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<MeshHeading>
<DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D004196" MajorTopicYN="Y">Disease Outbreaks</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D017052" MajorTopicYN="N">Hospital Mortality</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D053118" MajorTopicYN="Y">Influenza A Virus, H1N1 Subtype</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D007843" MajorTopicYN="N">Latin America</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D011251" MajorTopicYN="N">Pregnancy Complications, Infectious</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012042" MajorTopicYN="N">Registries</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012131" MajorTopicYN="N">Respiratory Insufficiency</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D012769" MajorTopicYN="N">Shock</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="received">
<Year>2009</Year>
<Month>12</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised">
<Year>2009</Year>
<Month>12</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2009</Year>
<Month>12</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2010</Year>
<Month>1</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
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<Month>1</Month>
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<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2010</Year>
<Month>5</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">20061066</ArticleId>
<ArticleId IdType="pii">S0210-5691(09)00173-9</ArticleId>
<ArticleId IdType="doi">10.1016/j.medin.2009.12.005</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>Espagne</li>
</country>
</list>
<tree>
<noCountry>
<name sortKey="Albaya Moreno, A" sort="Albaya Moreno, A" uniqKey="Albaya Moreno A" first="A" last="Albaya-Moreno">A. Albaya-Moreno</name>
<name sortKey="Algora Weber, A" sort="Algora Weber, A" uniqKey="Algora Weber A" first="A" last="Algora-Weber">A. Algora-Weber</name>
<name sortKey="Balasini, C" sort="Balasini, C" uniqKey="Balasini C" first="C" last="Balasini">C. Balasini</name>
<name sortKey="Barahona, D" sort="Barahona, D" uniqKey="Barahona D" first="D" last="Barahona">D. Barahona</name>
<name sortKey="Figueira, J C" sort="Figueira, J C" uniqKey="Figueira J" first="J C" last="Figueira">J C Figueira</name>
<name sortKey="Gonzalez, N" sort="Gonzalez, N" uniqKey="Gonzalez N" first="N" last="González">N. González</name>
<name sortKey="Guerrero, J E" sort="Guerrero, J E" uniqKey="Guerrero J" first="J E" last="Guerrero">J E Guerrero</name>
<name sortKey="Le N Gil, C" sort="Le N Gil, C" uniqKey="Le N Gil C" first="C" last="Le N-Gil">C. Le N-Gil</name>
<name sortKey="Lisboa, T" sort="Lisboa, T" uniqKey="Lisboa T" first="T" last="Lisboa">T. Lisboa</name>
<name sortKey="Lorente, L" sort="Lorente, L" uniqKey="Lorente L" first="L" last="Lorente">L. Lorente</name>
<name sortKey="Maravi Poma, E" sort="Maravi Poma, E" uniqKey="Maravi Poma E" first="E" last="Maraví-Poma">E. Maraví-Poma</name>
<name sortKey="Martin, M" sort="Martin, M" uniqKey="Martin M" first="M" last="Martín">M. Martín</name>
<name sortKey="Perez Padilla, R" sort="Perez Padilla, R" uniqKey="Perez Padilla R" first="R" last="Pérez-Padilla">R. Pérez-Padilla</name>
<name sortKey="Rello, J" sort="Rello, J" uniqKey="Rello J" first="J" last="Rello">J. Rello</name>
<name sortKey="Socias, L" sort="Socias, L" uniqKey="Socias L" first="L" last="Socías">L. Socías</name>
<name sortKey="Valles, J" sort="Valles, J" uniqKey="Valles J" first="J" last="Vallés">J. Vallés</name>
<name sortKey="Villab N, M" sort="Villab N, M" uniqKey="Villab N M" first="M" last="Villab N">M. Villab N</name>
</noCountry>
<country name="Espagne">
<noRegion>
<name sortKey="Rodriguez, A" sort="Rodriguez, A" uniqKey="Rodriguez A" first="A" last="Rodríguez">A. Rodríguez</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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